Formamicin, a Novel Antifungal Antibiotic Produced by a Strain of Saccharothvix sp. I. Taxonomy, Production, Isolation and Biological Properties

MASAYUKI IGARASHI; NAOKO KINOSHITA; TAKAKO IKEDA; EIKO NAKAGAWA; MASA HAMADA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.50.926

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Formamicin, a Novel Antifungal Antibiotic Produced by a Strain of Saccharothvix sp.

I. Taxonomy, Production, Isolation and Biological Properties

MASAYUKI IGARASHI, NAOKO KINOSHITA, TAKAKO IKEDA, EIKO NAKAGAWA, MASA HAMADA, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 11 Pages 926-931

DOI https://doi.org/10.7164/antibiotics.50.926

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Abstract

Formamicin, an antifungal antibiotic, was isolated from the cultured broth of an actinomycete strain. The strain was isolated from a soil collected at Setagaya-ku, Tokyo, Japan, and identified as Saccharothrix sp. MK27-91F2.
Formamicin was extracted with acetone from cultured mycelia and purified by silicagel and Sephadex LH-20 column chromatographies and CPC (Centrifugal liquid-liquid Partition Chromatography).
Formamicin showed strong antimicrobial activity against phytopathogenic fungi.

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