NF00659A₁, A₂, A₃, B₁ and B₂, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659

II. Structural Elucidation

Abstract

NF00659A₁, A₂, A₃, B₁ and B₁2, having insecticidal and antitumor activities, were isolated from a culture mycelium of Aspergillus sp. NF 00659. The novel structure of NF00659s were determined mainly by spectroscopic studies including various NMR measurements. NF00659s have a common structure which consists of acyl, α-pyrone and 4, 5-seco-tricyclic diterpene moieties.