Cyclothialidine Analogs, Novel DNA Gyrase Inhibitors

KAYOKO YAMAJI; MIYAKO MASUBUCHI; FUMIKO KAWAHARA; YUMIKO NAKAMURA; AYA NISHIO; SHOKO MATSUKUMA; MIKAKO FUJIMORI; NAOKI NAKADA; JUNKO WATANABE; TSUTOMU KAMIYAMA

doi:10.7164/antibiotics.50.402

KAYOKO YAMAJI, MIYAKO MASUBUCHI, FUMIKO KAWAHARA, YUMIKO NAKAMURA, AYA NISHIO, SHOKO MATSUKUMA, MIKAKO FUJIMORI, NAOKI NAKADA, JUNKO WATANABE, TSUTOMU KAMIYAMA

Author information

KAYOKO YAMAJI
Nippon Roche Research Center
MIYAKO MASUBUCHI
Nippon Roche Research Center
FUMIKO KAWAHARA
Nippon Roche Research Center
YUMIKO NAKAMURA
Nippon Roche Research Center
AYA NISHIO
Nippon Roche Research Center
SHOKO MATSUKUMA
Nippon Roche Research Center
MIKAKO FUJIMORI
Nippon Roche Research Center
NAOKI NAKADA
Nippon Roche Research Center
JUNKO WATANABE
Nippon Roche Research Center
TSUTOMU KAMIYAMA
Nippon Roche Research Center

JOURNAL FREE ACCESS

1997 Volume 50 Issue 5 Pages 402-411

DOI https://doi.org/10.7164/antibiotics.50.402

Details

Abstract

DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates. Cyclothialidines B, D and E are novel and potent inhibitors of DNA gyrase.

Corresponding author

Register with J-STAGE for free!