The Journal of Antibiotics
Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora
I. Taxonomy, Fermentation, Isolation, and Biological Activities
FRANCISCO ROMEROFERNANDO ESPLIEGOJULIA PÉREZ BAZTERESA GARCÍA DE QUESADADOLORES GRÁVALOSFERNANDO DE LA CALLEJOSÉ LUIS FERNÁNDEZ-PUENTES
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Volume 50 (1997) Issue 9 Pages 734-737

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Abstract

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.

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