Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora I. Taxonomy, Fermentation, Isolation, and Biological Activities

FRANCISCO ROMERO; FERNANDO ESPLIEGO; JULIA PÉREZ BAZ; TERESA GARCÍA DE QUESADA; DOLORES GRÁVALOS; FERNANDO DE LA CALLE; JOSÉ LUIS FERNÁNDEZ-PUENTES

doi:10.7164/antibiotics.50.734

Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora

I. Taxonomy, Fermentation, Isolation, and Biological Activities

FRANCISCO ROMERO, FERNANDO ESPLIEGO, JULIA PÉREZ BAZ, TERESA GARCÍA DE QUESADA, DOLORES GRÁVALOS, FERNANDO DE LA CALLE, JOSÉ LUIS FERNÁNDEZ-PUENTES

著者情報

ジャーナルフリー

1997 年 50 巻 9 号 p. 734-737

DOI https://doi.org/10.7164/antibiotics.50.734

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抄録

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.

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