Cytotoxic Substances Produced by a Fungal Strain from a Sponge: Physico-chemical Properties and Structures

Abstract

Five novel metabolites, trichodenones A∼C (1∼3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1∼3 exhibited significant cytotoxicity against cultured P388 cells.