The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Cytotoxic Substances Produced by a Fungal Strain from a Sponge: Physico-chemical Properties and Structures
TARO AMAGATAYOSHIHIDE USAMIKATSUHIKO MINOURATADAYOSHI ITOATSUSHI NUMATA
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1998 Volume 51 Issue 1 Pages 33-40

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Abstract

Five novel metabolites, trichodenones A∼C (13), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 13 exhibited significant cytotoxicity against cultured P388 cells.

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