Isolation and Characterisation of an Antifungal Antibiotic (GR135402) with Protein Synthesis Inhibition

O. S. KINSMAN; P. A. CHALK; H. C. JACKSON; R. F. MIDDLETON; A. SHUTTLEWORTH; B. A. M. RUDD; C. A. JONES; H. M. NOBLE; H. G. WILDMAN; M. J. DAWSON; C. STYLLI; P. J. SIDEBOTTOM; B. LAMONT; S. LYNN; M. V. HAYES

doi:10.7164/antibiotics.51.41

O. S. KINSMAN, P. A. CHALK, H. C. JACKSON, R. F. MIDDLETON, A. SHUTTLEWORTH, B. A. M. RUDD, C. A. JONES, H. M. NOBLE, H. G. WILDMAN, M. J. DAWSON, C. STYLLI, P. J. SIDEBOTTOM, B. LAMONT, S. LYNN, M. V. HAYES

Author information

O. S. KINSMAN
Glaxo Wellcome Research and Development
P. A. CHALK
Glaxo Wellcome Research and Development
H. C. JACKSON
Glaxo Wellcome Research and Development
R. F. MIDDLETON
Glaxo Wellcome Research and Development
A. SHUTTLEWORTH
Glaxo Wellcome Research and Development
B. A. M. RUDD
Glaxo Wellcome Research and Development
C. A. JONES
Glaxo Wellcome Research and Development
H. M. NOBLE
Glaxo Wellcome Research and Development
H. G. WILDMAN
Glaxo Wellcome Research and Development
M. J. DAWSON
Glaxo Wellcome Research and Development
C. STYLLI
Glaxo Wellcome Research and Development
P. J. SIDEBOTTOM
Glaxo Wellcome Research and Development
B. LAMONT
Glaxo Wellcome Research and Development
S. LYNN
Glaxo Wellcome Research and Development
M. V. HAYES
Glaxo Wellcome Research and Development

JOURNAL FREE ACCESS

1998 Volume 51 Issue 1 Pages 41-49

DOI https://doi.org/10.7164/antibiotics.51.41

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Abstract

A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.

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