WA8242A1, A2 and B, Novel Secretory Phospholipase A2 Inhibitors Produced by Streptomyces violaceusniger II. Biological Properties

SEIJI YOSHIMURA; TAKANAO OTSUKA; YUKO MURAMATSU; TATSUJIRO FUJIWARA; MASANORI OKAMOTO; SEIJI HASHIMOTO; MASAKUNI OKUHARA

doi:10.7164/antibiotics.51.8

WA8242A₁, A₂ and B, Novel Secretory Phospholipase A₂ Inhibitors Produced by Streptomyces violaceusniger

II. Biological Properties

SEIJI YOSHIMURA, TAKANAO OTSUKA, YUKO MURAMATSU, TATSUJIRO FUJIWARA, MASANORI OKAMOTO, SEIJI HASHIMOTO, MASAKUNI OKUHARA

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JOURNAL FREE ACCESS

1998 Volume 51 Issue 1 Pages 8-13

DOI https://doi.org/10.7164/antibiotics.51.8

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Abstract

WA8242A₁, A₂ and B, novel inhibitors of secretory phospholipase A₂ (PLA₂), were obtained from Streptomyces violaceusniger No. 8242. WA8242B inhibited secretory group I and II PLA₂s in a dose-dependent manner. The mode of inhibition of group II PLA₂ by WA8242B was in competitive fashion. WA8242B inhibited group II PLA₂-induced Prostaglandin I₂ (PGI₂) production by human umbilical vein endothelial cells. Furthermore, WA8242B was effective in mouse zymosan writhing model.

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