Glisoprenins C, D and E, New Inhibitors of Appressorium Formation in Magnaporthe grisea, from Cultures of Gliocladium roseum

1. Production and Biological Activities

Abstract

Glisoprenins C, D, and E, new glisoprenin derivatives, were isolated together with glisoprenin A from submerged cultures of the deuteromycete Gliocladium roseum HA190-95. All glisoprenins inhibited appressorium formation in Magnaporthe grisea on inductive (hydrophobic) surfaces. The compounds exhibited moderate cytotoxic, but no antifungal, antibacterial or phytotoxic activities.