Cremimycin, a Novel 19-Membered Macrocyclic Lactam Antibiotic, from Streptomyces sp.

MASAYUKI IGARASHI; TOSHIO TSUCHIDA; NAOKO KINOSHITA; MIE KAMIJIMA; RYUICHI SAWA; TSUTOMU SAWA; HIROSHI NAGANAWA; MASA HAMADA; TOMIO TAKEUCHI; KATSUHISA YAMAZAKI; MASAAKI ISHIZUKA

doi:10.7164/antibiotics.51.123

Cremimycin, a Novel 19-Membered Macrocyclic Lactam Antibiotic, from Streptomyces sp.

MASAYUKI IGARASHI, TOSHIO TSUCHIDA, NAOKO KINOSHITA, MIE KAMIJIMA, RYUICHI SAWA, TSUTOMU SAWA, HIROSHI NAGANAWA, MASA HAMADA, TOMIO TAKEUCHI, KATSUHISA YAMAZAKI, MASAAKI ISHIZUKA

Author information

MASAYUKI IGARASHI
Institute of Microbial Chemistry
TOSHIO TSUCHIDA
Institute of Microbial Chemistry
NAOKO KINOSHITA
Institute of Microbial Chemistry
MIE KAMIJIMA
Institute of Microbial Chemistry
RYUICHI SAWA
Institute of Microbial Chemistry
TSUTOMU SAWA
Institute of Microbial Chemistry
HIROSHI NAGANAWA
Institute of Microbial Chemistry
MASA HAMADA
Institute of Microbial Chemistry
TOMIO TAKEUCHI
Institute of Microbial Chemistry
KATSUHISA YAMAZAKI
Institute for Chemotherapy
MASAAKI ISHIZUKA
Institute for Chemotherapy

JOURNAL FREE ACCESS

1998 Volume 51 Issue 2 Pages 123-129

DOI https://doi.org/10.7164/antibiotics.51.123

Details

Abstract

A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl₃-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study.
Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.

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