The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity:
Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities
KOEN A. DEKKERTAISUKE INAGAKITHOMAS D. GOOTZLIANG H. HUANGYASUHIRO KOJIMAWILLIAM E. KOHLBRENNERYASUE MATSUNAGAPAUL R. MCGUIRKETSUKO NOMURATATSUO SAKAKIBARASHINICHI SAKEMIYUMIKO SUZUKIYUJI YAMAUCHINAKAO KOJIMA
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1998 Volume 51 Issue 2 Pages 145-152

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Abstract

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other micro-organisms.

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