The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Antimalarial Activity of Radicicol, Heptelidic Acid and Other Fungal Metabolites
YOSHITAKE TANAKAKAZURO SHIOMIKISEKO KAMEIMASAKO SUGOH-HAGINOYUMI ENOMOTOFANG FANGYUUICHI YAMAGUCHIROKURO MASUMACHENG GANG ZHANGXIAN WU ZHANGSATOSHI OMURA
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1998 Volume 51 Issue 2 Pages 153-160

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Abstract

In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.

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