Antimalarial Activity of Radicicol, Heptelidic Acid and Other Fungal Metabolites

YOSHITAKE TANAKA; KAZURO SHIOMI; KISEKO KAMEI; MASAKO SUGOH-HAGINO; YUMI ENOMOTO; FANG FANG; YUUICHI YAMAGUCHI; ROKURO MASUMA; CHENG GANG ZHANG; XIAN WU ZHANG; SATOSHI OMURA

doi:10.7164/antibiotics.51.153

YOSHITAKE TANAKA, KAZURO SHIOMI, KISEKO KAMEI, MASAKO SUGOH-HAGINO, YUMI ENOMOTO, FANG FANG, YUUICHI YAMAGUCHI, ROKURO MASUMA, CHENG GANG ZHANG, XIAN WU ZHANG, SATOSHI OMURA

Author information

YOSHITAKE TANAKA
Research Center for Biological Function, The Kitasato Institute
KAZURO SHIOMI
Research Center for Biological Function, The Kitasato Institute
KISEKO KAMEI
Department of Parasitology, Teikyo University School of Medicine
MASAKO SUGOH-HAGINO
Research Center for Biological Function, The Kitasato Institute
YUMI ENOMOTO
Research Center for Biological Function, The Kitasato Institute
FANG FANG
Research Center for Biological Function, The Kitasato Institute
YUUICHI YAMAGUCHI
Research Center for Biological Function, The Kitasato Institute
ROKURO MASUMA
Research Center for Biological Function, The Kitasato Institute
CHENG GANG ZHANG
The Institute of Applied Ecology, Shenyang Academy of Sciences
XIAN WU ZHANG
The Institute of Applied Ecology, Shenyang Academy of Sciences
SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute

JOURNAL FREE ACCESS

1998 Volume 51 Issue 2 Pages 153-160

DOI https://doi.org/10.7164/antibiotics.51.153

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Abstract

In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.

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