Synthesis and Activities of Bactobolin Derivatives Based on the Alteration of the Functionality at C-3 Position

Abstract

Some derivatives of bactobolin were prepared from bactobolin (1) by radical reduction and formation of the fused azetidine ring. The derivatives proved less active than the parent antibiotic 1 against bacteria, indicating that dichloromethyl group at C-3 position play an important role in biological activity.