Fattiviracin A1, a Novel Antiherpetic Agent Produced by Streptomyces microflavus Strain No. 2445

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation

Abstract

A novel antiherpetic agent, fattiviracin A1, was isolated from the culture broth of strain No. 2445 identified as Streptomyces microflavus. It was purified through 1-butanol extraction, column chromatographies on Diaion HP-10 and silica gel and HPLC using a reverse phase column. The structure of fattiviracin A1 was determined by several spectroscopic experiments and chemical degradations. It is a new macrocyclic diester consisting of four D-glucose units and two (C₂₄ and C₃₃) hydroxy fatty acids. It is closely related to cycloviracins B₁ and B₂, but differs from these known compounds in both the length of its side chain and the sugar moiety.