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The Journal of Antibiotics
Vol. 52 (1999) No. 6 P 525-530

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http://doi.org/10.7164/antibiotics.52.525


We performed experiments to screen for neutral sphingomyelinase inhibitors using rat brain microsomes as an enzyme source. Among more than 10, 000 microbial extracts tested, a mycelial extract of Trichopeziza mollissima SANK 13892 exhibited potent inhibitory activity. The active compound, scyphostatin, was purified by a series of chromatographies. Scyphostatin inhibited the enzyme with an IC50 value of 1.0 μM.

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