The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1
Taxonomy, Fermentation, Isolation and Biological Activities
KOICHI NAKAEYUYA YOSHIMOTOTSUTOMU SAWAYOSHIKO HOMMAMASA HAMADATOMIO TAKEUCHMASAYA IMOTO
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2000 Volume 53 Issue 10 Pages 1130-1136

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Abstract

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC 17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

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