The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Cjcclo(Dehydroala-L-Leu), an α-Glucosidase Inhibitor from Penicillium sp. F7Q6l4
OH SUNG KWONSANG HO PARKBONG-SIK YUNYU RYANG PYUNCHANG-JIN KIM
Author information
JOURNALS FREE ACCESS

Volume 53 (2000) Issue 9 Pages 954-958

Details
Abstract

A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC50 values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.

Information related to the author
© Japan Antibiotics Research Association
Previous article Next article

Recently visited articles
feedback
Top