New Pyrrolizidinone Antibiotics CJ-16, 264 and CJ-16, 367

YUTAKA SUGIE; HIDEO HIRAI; HIROKO KACHI-TONAI; YOON-JEONG KIM; YASUHIRO KOJIMA; YUKIO SHIOMI; AKEMI SUGIURA; AYUMU SUGIURA; YUMIKO SUZUKI; NOBUJI YQSHIKAWA; LORI BRENNAN; JOAN DUIGNAN; LIANG HSIUNG HUANG; JOYCE SUTCLIFFE; NAKAO KOJIMA

doi:10.7164/antibiotics.54.917

YUTAKA SUGIE, HIDEO HIRAI, HIROKO KACHI-TONAI, YOON-JEONG KIM, YASUHIRO KOJIMA, YUKIO SHIOMI, AKEMI SUGIURA, AYUMU SUGIURA, YUMIKO SUZUKI, NOBUJI YQSHIKAWA, LORI BRENNAN, JOAN DUIGNAN, LIANG HSIUNG HUANG, JOYCE SUTCLIFFE, NAKAO KOJIMA

Author information

YUTAKA SUGIE
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
HIDEO HIRAI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
HIROKO KACHI-TONAI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YOON-JEONG KIM
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YUKIO SHIOMI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
AKEMI SUGIURA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
AYUMU SUGIURA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YUMIKO SUZUKI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
NOBUJI YQSHIKAWA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
LORI BRENNAN
PGRD, Groton Laboratories, Pfizer Inc.
JOAN DUIGNAN
PGRD, Groton Laboratories, Pfizer Inc.
LIANG HSIUNG HUANG
PGRD, Groton Laboratories, Pfizer Inc.
JOYCE SUTCLIFFE
PGRD, Groton Laboratories, Pfizer Inc.
NAKAO KOJIMA
Faculty of Pharmacy, Meijo University

JOURNAL FREE ACCESS

2001 Volume 54 Issue 11 Pages 917-925

DOI https://doi.org/10.7164/antibiotics.54.917

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Abstract

Two new antibiotics, CJ-16, 264 (I) and CJ-16, 367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.

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