J-STAGE Home  >  Publications - Top  > Bibliographic Information

The Journal of Antibiotics
Vol. 54 (2001) No. 12 P 1013-1018

Language:

http://doi.org/10.7164/antibiotics.54.1013


Glutamate, an excitatory amino acid, is known to induce neurotoxicity in central nervous system under abnormal conditions such as ischemia, hypoglycemia, epilepsy, Huntington's chorea, Parkinson's disease and Alzheimer's disease. In our search for neuroprotective agents of microbial origin against excitatory neurotoxins, we have isolated two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound complestatin, from the fermentation broth of Streptomyces sp. Q27107. Neuroprotectins protected primary cultured chick telencephalic neurons from glutamate- and kainate-induced excitotoxicities in a dose-dependant fashion.

Copyright © Japan Antibiotics Research Association

Article Tools

Share this Article