CJ-15, 801, a Novel Antibiotic from a Fungus, Seimatosporium sp.

YUTAKA SUGIE; KOEN A. DEKKER; HIDEO HIRAI; TOSHIO ICHIBA; MASARU ISHIGURO; YUKIO SHIONI; AKEMI SUGIURA; LORI BRENNAN; JOAN DUIGNAN; LIANG HSIUNG HUANG; JOYCE SUTCLIFFE; YASUHIRO KOJIMA

doi:10.7164/antibiotics.54.1060

CJ-15, 801, a Novel Antibiotic from a Fungus, Seimatosporium sp.

YUTAKA SUGIE, KOEN A. DEKKER, HIDEO HIRAI, TOSHIO ICHIBA, MASARU ISHIGURO, YUKIO SHIONI, AKEMI SUGIURA, LORI BRENNAN, JOAN DUIGNAN, LIANG HSIUNG HUANG, JOYCE SUTCLIFFE, YASUHIRO KOJIMA

Author information

YUTAKA SUGIE
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
KOEN A. DEKKER
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
HIDEO HIRAI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
TOSHIO ICHIBA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
MASARU ISHIGURO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YUKIO SHIONI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
AKEMI SUGIURA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
LORI BRENNAN
PGRD, Groton Laboratories, Pfizer Inc.
JOAN DUIGNAN
PGRD, Groton Laboratories, Pfizer Inc.
LIANG HSIUNG HUANG
PGRD, Groton Laboratories, Pfizer Inc.
JOYCE SUTCLIFFE
PGRD, Groton Laboratories, Pfizer Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

JOURNAL FREE ACCESS

2001 Volume 54 Issue 12 Pages 1060-1065

DOI https://doi.org/10.7164/antibiotics.54.1060

Details

Abstract

A novel antibiotic, CJ-15, 801 (I), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an α, β-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50μml

Corresponding author

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