The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
S-15183a and b, New Sphingosine Kinase Inhibitors, Produced by a Fungus
KEITA KONOMASAHIRO TANAKAYASUNORI ONOTSUYOSHI HOSOYATAKESHI OGITATAKAFUMI KOHAMA
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2001 Volume 54 Issue 5 Pages 415-420

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Abstract

In the course of our screening for inhibitors of sphingosine kinase, we found two active compounds in a culture broth of a fungus, Zopfiella inermis SANK 15183. The structures of the compounds, named S-15183a and b, were elucidated by a combination of spectroscopic analyses to be new azaphilone-type metabolites. S-15183a and b inhibited sphingosine kinase from rat liver with IC50 values of 2.5 and 1.6μM, respectively. S-15183a also inhibited endogenous SPH kinase activity in intact platelets.

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