SNF4435C and D, Novel Imimmosuppressants Produced by a Strain of Streptomyces spectabilis II. Structure Elucidation

KOSAKU TAKAHASHI; EISUKE TSUDA; KAZUHIKO KUROSAWA

doi:10.7164/antibiotics.54.548

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SNF4435C and D, Novel Imimmosuppressants Produced by a Strain of Streptomyces spectabilis

II. Structure Elucidation

KOSAKU TAKAHASHI, EISUKE TSUDA, KAZUHIKO KUROSAWA

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2001 Volume 54 Issue 7 Pages 548-553

DOI https://doi.org/10.7164/antibiotics.54.548

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Abstract

SNF4435C and D are new immunosuppressants isolated from the culture broth of a strain of Streptomyces spectabilis. Their molecular formulas were determined as C₂₈H₃₁NO₆ based on the HRFAB-MS analyses. The structures of SNF4435C and D were elucidated to be novel nitrophenyl pyrones having an intriguing tricyclic ring system and diastereoisomers of each other by spectroscopic analyses including various NMR measurements.

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