The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
An Efficient Screening Approach for Anti-Microcystis Compounds Based on Knowledge of Aquatic Microbial Ecosystem
NOBUTAKA IMAMURAIZUMI MOTOIKENAOKO SHIMADAMAKIKO NISHIKORIHISAO MORISAKIHIROSHI FUKAMI
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2001 Volume 54 Issue 7 Pages 582-587

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Abstract

To improve the efficiency of screening for anti-Microcystis compounds, we planned to use algae-lysing bacteria that kill the organisms of water blooms. A two step-screening process was carried out, i.e., the screening of algae-lysing bacteria and the selection of anti-Microcystis producers from the bacteria. Sources for the isolation of the bacteria were a co-cultivated fluid of a water sample with axenic Microcystis viridis, a water sample collected in a water bloom season, and a water bloom sample. The water bloom sample was the best source for the isolation of the algae-lysing bacteria and such bacteria were shown to exhibit potent activity. Seventeen strains out of 20 isolated algae-lysing bacteria produced anti-Microcystis activities, and one of the principles was the previously reported argimicin A. These results indicate that algae-lysing bacteria in water blooms may be good sources for potent and selective anticyanobacterial compounds.

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