CJ-21, 058, a New SecA Inhibitor Isolated from a Fungus

YUTAKA SUGIE; SAE INAGAKI; YOSHINAO KATO; HIROYUKI NISHIDA; CHANG-HONG PANG; TOSHIYUKI SAITO; SHINICHI SAKEMI; FADIA DIB-HAJJ; JOHN P. MUELLER; JOYCE SUTCLIFFE; YASUHIRO KOJIMA

doi:10.7164/antibiotics.55.25

YUTAKA SUGIE, SAE INAGAKI, YOSHINAO KATO, HIROYUKI NISHIDA, CHANG-HONG PANG, TOSHIYUKI SAITO, SHINICHI SAKEMI, FADIA DIB-HAJJ, JOHN P. MUELLER, JOYCE SUTCLIFFE, YASUHIRO KOJIMA

Author information

YUTAKA SUGIE
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
SAE INAGAKI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YOSHINAO KATO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
HIROYUKI NISHIDA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
CHANG-HONG PANG
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
TOSHIYUKI SAITO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
SHINICHI SAKEMI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
FADIA DIB-HAJJ
PGRD, Groton Laboratories, Pfizer Inc.
JOHN P. MUELLER
PGRD, Groton Laboratories, Pfizer Inc.
JOYCE SUTCLIFFE
PGRD, Groton Laboratories, Pfizer Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

JOURNAL FREE ACCESS

2002 Volume 55 Issue 1 Pages 25-29

DOI https://doi.org/10.7164/antibiotics.55.25

Details

Abstract

A new equisetin derivative, CJ-21, 058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane.

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