The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Biologically Active Secondary Metabolites from the Ascomycete A111-95
1. Production, Isolation and Biological Activities
BÄRBEL KÖPCKEMARTIN JOHANSSONOLOV STERNERHEIDRUN ANKE
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2002 Volume 55 Issue 1 Pages 36-40

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Abstract

Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.

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