Synthesis of Milbemycins α₉, α₁₀, α₁₁, α₁₂, α₁₄, α₁₅, α₂₀, α₂₁, α₂₂, α₂₃, α₂₆, α₂₇, Δ^{2, 3}, Δ^{4, 26}-Milbemycins A₃, A₄ from Milbemycins

Abstract

Chemical derivation methods to prepare 26-acyloxy and 26-hydroxymilbemycins, which had been reported as natural products, milbemycins α₉, α₁₀, α₁₁, α₁₂, α₁₄, α₁₅, α₂₀, α₂₁, α₂₂, α₂₃, α₂₆, α₂₇ from milbemycins A₃, A₄ were reported. Δ^{2, 3}, Δ^{4, 26}-Milbemycins A₃, A₄, which had also been reported as natural products, were further prepared from milbemycins A₃, A₄. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.