YM-202204, a New Antifungal Antibiotic Produced by Marine Fungus Phoma sp.

KOJI NAGAI; KAZUMA KAMIGIRI; HISAO MATSUMOTO; YASUHIRO KAWANO; MASAKAZU YAMAOKA; HITOSHI SHIMOI; MASATO WATANABE; KENICHI SUZUKI

doi:10.7164/antibiotics.55.1036

YM-202204, a New Antifungal Antibiotic Produced by Marine Fungus Phoma sp.

KOJI NAGAI, KAZUMA KAMIGIRI, HISAO MATSUMOTO, YASUHIRO KAWANO, MASAKAZU YAMAOKA, HITOSHI SHIMOI, MASATO WATANABE, KENICHI SUZUKI

Author information

KOJI NAGAI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
KAZUMA KAMIGIRI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
HISAO MATSUMOTO
Analysis & Metabolism Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
YASUHIRO KAWANO
Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology
MASAKAZU YAMAOKA
Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology
HITOSHI SHIMOI
National Research Institute of Brewing
MASATO WATANABE
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
KENICHI SUZUKI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

2002 Volume 55 Issue 12 Pages 1036-1041

DOI https://doi.org/10.7164/antibiotics.55.1036

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Abstract

A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.

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