The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Kosinostatin, a Quinocycline Antibiotic with Antitumor Activity from Micromonospora sp. TP-A0468
TAMOTSU FURUMAIYASUHIRO IGARASHIHIROKO HIGUCHINORIKO SAITOTOSHIKAZU OKI
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2002 Volume 55 Issue 2 Pages 128-133

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Abstract

Kosinostatin, a quinocycline antibiotic was isolated from the culture broth of an actinomycete strain TP-A0468 along with isoquinocycline B. The producing strain was isolated from the seawater sample collected in Toyama Bay and identified as Micromonospora sp. based on the taxonomic study. Kosinostatin was obtained from the culture fluid by solvent extraction and ODS column chromatography. Kosinostatin inhibited the growth of Gram-positive bacteria strongly (MIC=0.039μg/ml) and Gram-negative bacteria and yeasts moderately (MIC=1.56-12.5μg/ml). It showed cytotoxicity against various cancer cell lines with the IC50 of 0.02-0.6μM and inhibited human DNA topoisomerase IIα with the IC50 of 3-10μM.

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