The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Neosordarin and Hydroxysordarin, Two New Antifungal Agents from Sordaria araneosa
PAOLO DAVOLIGÜNTHER ENGELANDREAS WERLEOLOV STERNERTIMM ANKE
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2002 Volume 55 Issue 4 Pages 377-382

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Abstract

Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose moiety. Hydroxysordarin (3) closely resembles sordarin (4), the only slight difference being the replacement of sordarose with altrose as the sugar unit.

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