Radamycin, a Novel Thiopeptide Produced by Streptomyces sp. RSP9 II. Physico-chemical Properties and Structure Determination

JULIÁN CASTRO RODRÍGUEZ; GLORIA GONZÁLEZ HOLGADO; RAMÓN I. SANTAMARÍA SÁNCHEZ; LIBRADA M. CAÑEDO

doi:10.7164/antibiotics.55.391

Radamycin, a Novel Thiopeptide Produced by Streptomyces sp. RSP9

II. Physico-chemical Properties and Structure Determination

JULIÁN CASTRO RODRÍGUEZ, GLORIA GONZÁLEZ HOLGADO, RAMÓN I. SANTAMARÍA SÁNCHEZ, LIBRADA M. CAÑEDO

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JOURNAL FREE ACCESS

2002 Volume 55 Issue 4 Pages 391-395

DOI https://doi.org/10.7164/antibiotics.55.391

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Abstract

The new cyclic peptide antibiotic, radamycin (1) and the known thiopeptide methylsulfomycin I (2) have been isolated from the fermentation broth of a Streptomyces sp. RSP9. The structure of radamycin was elucidated by NMR, LC-MS and FAB-MS and was established as a thiopeptide with oxazole and thiazole moieties, and several unusual amino acids.

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