Novel α-Glucosidase Inhibitors, CKD-711 and CKD-711a Produced by Streptomyces sp. CK-4416

I. Taxonomy, Fermentation and Isolation

Abstract

New α-glucosidase inhibitors, CKD-711 and CKD-711a were produced from the fermentation broth of Streptomyces sp. CK-4416 which was isolated from a forest soil of Jeju Island, South Korea. CKD-711 and CKD-711a were purified by Dowex 50W-2X and Sephadex G-10 column chromatography. In in vitro studies, CKD-711 showed a potent inhibitory activity against α-glucosidase from mammalian, but less inhibition against α-amylase from microorganism and mammalian. CKD-711a showed a lower inhibitory activity than CKD-711.