The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus
I. Taxonomy, Fermentation, Isolation and Biological Activities
KLAUS GEBHARDTJUDITH SCHIMANAPHILIPP KRASTELKONRAD DETTNERJOACHIM RHEINHEIMERAXEL ZEECKHANS-PETER FIEDLER
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2002 Volume 55 Issue 9 Pages 794-800

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Abstract

Four new members of the phenazine family, endophenazines A-D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).

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