The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Cyrmenins, New β-Methoxyacrylate Inhibitors of the Electron Transport Production, Isolation, Physico-chemical and Biological Properties
FLORENZ SASSETHOMAS LEIBOLDBRIGITTE KUNZEGERHARD HÖFLEHANS REICHENBACH
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2003 Volume 56 Issue 10 Pages 827-831

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Abstract

New antibiotic compounds, named cyrmenins, were isolated from the culture broth of strains of the myxobacteria Cystobacter armeniaca and Archangium gephyra. The compounds belong to the group of β-methoxyacrylate (MOA) inhibitors and are the first naturally occuring nitrogen-linked MOAs. The cyrmenins show nearly the same antifungal activity as strobilurin A, but are less toxic in a growth inhibition assay with L929 mouse cells. Cyrmenins inhibit NADH oxidation by submitochondrial particles from beef heart. Investigations by difference spectroscopy showed that cyrmenin B1 blocks the electron transport within the cytochrome bc1-segment (complex III) of the respiratory chain.

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