Arborcandins A, B, C, D, E and F, Novel 1, 3-β-Glucan Synthase Inhibitors Physico-chemical Properties and Structure Elucidation

TAKAO OHYAMA; YUKO IWADATE-KURIHARA; TOMIO ISHIKAWA; SHUNICHI MIYAKOSHI; KIYOSHI HAMANO; MASATOSHI INUKAI

doi:10.7164/antibiotics.56.1024

Arborcandins A, B, C, D, E and F, Novel 1, 3-β-Glucan Synthase Inhibitors

Physico-chemical Properties and Structure Elucidation

TAKAO OHYAMA, YUKO IWADATE-KURIHARA, TOMIO ISHIKAWA, SHUNICHI MIYAKOSHI, KIYOSHI HAMANO, MASATOSHI INUKAI

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 12 Pages 1024-1032

DOI https://doi.org/10.7164/antibiotics.56.1024

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Abstract

Arborcandins A, B, C, D, E and F, which possess potent 1, 3-β-glucan synthase inhibitory activity, were isolated from the cultured broth of a filamentous fungus, strain SANK 17397. The structures of arborcandins A, B, C, D, E and F were elucidated by a combination of NMR and mass spectrometry, and established to be novel cyclic peptides containing uncommon amino acid residues.

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