The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Studies on Novel Bacterial Translocase I Inhibitors, A-500359s
I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation of A-500359 A, C, D and G
YASUNORI MURAMATSUAKIKO MURAMATSUTAKASHI OHNUKIMICHIKO MIYAZAWA ISHIIMASAAKI KIZUKARYUZO ENOKITASHINYA TSUTSUMIMASATOSHI ARAIYASUMASA OGAWATOSHIHIRO SUZUKITOSHIO TAKATSUMASATOSHI INUKAI
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2003 Volume 56 Issue 3 Pages 243-252

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Abstract

In the course of our screening for bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) inhibitors, we found inhibitory activity in the cultured broth of the strain identified as Streptomyces griseus SANK 60196. The strain produced capuramycin and four novel capuramycin derivatives designated as A-500359 A, C, D and G. Purification and structural analysis were performed, and the structures of A-500359 A, C, D and G were elucidated as 6"'-methylcapuramycin, 3'-demethyl-6"'-methylcapuramycin, 2"-deoxy-6"'-methylcapuramycin and 3'-demethylcapuramycin, respectively.

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