New Diketopiperazines from the Entomopathogenic Fungus Verticillium hemipterigenum BCC 1449

Abstract

Two new diketopiperazines, bisdethiodi (methylthio)-1-demethylhyalodendrin and 1-demethylhyalodendrin tetrasulfide, together with two known cyclodepsipeptides, enniatins B and B₄, and two known pyrones, pyrenocines A and B, were isolated from a culture broth of the entomopathogenic fungus Verticillium hemipterigenum BCC 1449. These structures were elucidated using spectroscopic methods and X-ray crystallography. Antimalarial and cytotoxic activities of these compounds were evaluated.