Structure of Tyroscherin, an Antitumor Antibiotic against IGF-1-dependent Cells from Pseudallescheria sp.

YOICHI HAYAKAWA; TOMOKI YAMASHITA; TOSHIYA MORI; KOJI NAGAI; KAZUO SHIN-YA; HIDENORI WATANABE

doi:10.7164/antibiotics.57.634

Structure of Tyroscherin, an Antitumor Antibiotic against IGF-1-dependent Cells from Pseudallescheria sp.

YOICHI HAYAKAWA, TOMOKI YAMASHITA, TOSHIYA MORI, KOJI NAGAI, KAZUO SHIN-YA, HIDENORI WATANABE

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JOURNAL FREE ACCESS

2004 Volume 57 Issue 10 Pages 634-638

DOI https://doi.org/10.7164/antibiotics.57.634

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Abstract

An antitumor antibiotic, tyroscherin, was isolated from the culture of a fungus identified as Pseudallescheria sp. The structure of tyroscherin including the absolute stereochemistry was determined as shown in Fig. 1 by NMR and degradation studies. Tyroscherin selectively inhibited IGF-1-dependent growth of MCF-7 human breast cancer cells with an IC₅₀ of 9.7ng/ml.

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