The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002
I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
MOTOO KOBAYASHIRYUICHI KANASAKIMASAMI EZAKIKAZUTOSHI SAKAMOTOSHIGEHIRO TAKASEAKIHIKO FUJIEMOTOHIRO HINOYASUHIRO HORI
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2004 Volume 57 Issue 12 Pages 780-787

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Abstract

A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatographies, and n-hexane precipitation. FR227244 is a white powder which melts at 210-211°C and possesses the molecular formula C38H58O11.
FR227244 is a novel triterpene glycoside with antifungal activity against Aspergillus fumigatus. The effects of FR227244 on the morphology of A. fumigatus were shown to be similar to those of FR901379 which is a known 1, 3-β-glucan synthase inhibitor.

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