The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Transvalencin A, a Thiazolidine Zinc Complex Antibiotic Produced by a Clinical Isolate of Nocardia transvalensis
I. Taxonomy, Fermentation, Isolation and Biological Activities
YASUTAKA HOSHINOAKIRA MUKAIKATSUKIYO YAZAWAJUN UNOJUN ISHIKAWAAKIKAZU ANDOTOSHIO FUKAIYUZURU MIKAMI
Author information
JOURNALS FREE ACCESS

2004 Volume 57 Issue 12 Pages 797-802

Details
Abstract

A new thiazolidine-type antibiotic with zinc in its structure, designated transvalencin A, was isolated from Nocardia sp. IFM 10065, a clinical isolate from a patient with actinomycotic mycetoma. The strain was identified as Nocardia transvalensis based on its morphological, phenotypic and phylogenetic characteristics. Transvalencin A showed antimicrobial activity against fungi such as Trichophyton mentagrophytes and Cryptococcus neoformans. The antibiotic is also active against Gram-positive bacteria such as Micrococcus luteus. We observed higher activity for fungi in an acidic medium than in a neutral medium.

Information related to the author
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top