The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107
I. Taxonomy, Fermentation, Isolation and Screening
TAKASHI SAKAITOMOHIRO SAMESHIMAMOTOKO MATSUFUJINAOTO KAWAMURAKAZUYUKI DOBASHIYOSHIHARU MIZUI
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2004 Volume 57 Issue 3 Pages 173-179

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Abstract

Seven new macrolides having a 12-membered ring, which we termed pladienolides, were isolated from the fermentation broth of Streptomyces platensis Mer-11107. Six of the seven pladienolides inhibited hypoxia-induced reporter gene expression controlled by human VEGF promoter with IC50 values of 0.0018-2.89μM. They also demonstrated growth-inhibitory activity against U251 human glioma cells in vitro. Pladienolides are highly potent inhibitors of both hypoxia signals and cancer cell proliferation, and thus may be useful as antitumor agents.

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