The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107
II. Physico-chemical Properties and Structure Elucidation
TAKASHI SAKAINAOKI ASAIAKIFUMI OKUDANAOTO KAWAMURAYOSHIHARU MIZUI
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2004 Volume 57 Issue 3 Pages 180-187

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Abstract

In the course of our screening using fermented broth from soil microorganisms, novel metabolites (pladienolides), possessing inhibitory activity against vascular endothelial growth factor (VEGF) expression and cancer cell proliferation, were isolated from Streptomyces platensis Mer-11107. Pladienolides A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were found to be novel 12-membered macrolides by spectroscopic studies including 1H, 13C NMR, HMQC, HMBC, and NOE experiments. Pladienolides are unusual 12-membered macrolides having a long side chain at the carbon that bears a lactone oxygen.

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