FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties

Abstract

FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis in human hepatoma cell line Hep G2. These compounds also have in vitro antifungal activity against Candida albicans and Aspergillus fumigatus.