Synthesis of Novel 26-Substituted Milbemycin A4 Derivatives and Their Acaricidal Activities

TAKAHIRO TSUKIYAMA; HISAKI KAJINO; YOSHIHISA TSUKAMOTO; HARUMI NAKAGAWA; TOSHIAKI YANAI; KAZUO SATO; SHINJI YOKOI; REIJI ICHINOSE; KEIJI TANAKA

doi:10.7164/antibiotics.57.446

Synthesis of Novel 26-Substituted Milbemycin A₄ Derivatives and Their Acaricidal Activities

TAKAHIRO TSUKIYAMA, HISAKI KAJINO, YOSHIHISA TSUKAMOTO, HARUMI NAKAGAWA, TOSHIAKI YANAI, KAZUO SATO, SHINJI YOKOI, REIJI ICHINOSE, KEIJI TANAKA

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JOURNAL FREE ACCESS

2004 Volume 57 Issue 7 Pages 446-455

DOI https://doi.org/10.7164/antibiotics.57.446

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Abstract

A series of novel 26-substituted milbemycin A₄ derivatives was synthesized from 5-O-t-butyldimethylsilyl-26-hydroxymilbemycin A₄ prepared by selenium dioxide oxidation of 5-O-t-butyldimethylsilyl-milbemycin A₄. Their acaricidal activities were assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.

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