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The Journal of Antibiotics
Vol. 57 (2004) No. 8 P 493-495



In a search for new inhibitors of the TNF-α promoter activity, a new spiro-compound, designated oxaspirodion, was obtained as a mixture of four isomers from fermentations of the ascomycete Chaetomium subspirale. The structure was determined by a combination of spectroscopic techniques.

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