Abstract
Blood levels of clindamycin-2-phosphate in dog at dosis of 10mg/kg body weight showed the maximum of 21μg/ml 30 seconds after one-shot i.v. administration. Continuous infusion of the antibiotic at the infusion speed of 150 and 300ml/hour/10kg b. w. with 6 mg/ml solution maintained blood levels of 30 and 170μg/ml respectively. It may be recommended clinically to use lower concentration than 6mg/ml to avoid cardiocirculatory disturbances.
Four cases of surgical mixed infections with gram-positive cocci, gram-negative bacilli and anaerobes were treated with clindamycin-2-phosphate at a daily dosis of 1,200mg intravenously and 2 of 4 cases revealed good clinical response. There was none of the haematological, hepatic, nephrotic, cardiocirculatory and allergic side effects.
