Abstract
Transfer of cefsulodin (CFS) into otorrhea and its clinical effectiveness for the infection caused by P.aeruginosain otorhinolaryngological field were evaluated and following results were obtained.
1. Transfer into otorrhea
One gram of CFS was administered to acute otitis media cases by one shot intravenous injection.CFS levels in otorrhea after 30, 60 minutes and 120 minutes of injection were 14.5, 20.3μg/g and 31.9μg/g respectively and the level at 120minutes was higher than that of serum, i.e.21.3μg/ml.In case of 1 gram CFS intravenous infusion for 1hour to acute exacerbation cases of chronic otitis media, CFS levels in otorrhea after 60 (at the completionof infusion), 120, 150, 180,240minutes and480minutes of the start of infusion were 2.1, 2.2, 1.3, 2.0, 4.3μg/g and 2.3μg/g respectively.
2. Clinical study
CFS was administered to5cases of infection caused by P.aeruginosa, i.e.2cases of otitis media and each 1 case of mastoiditis, auricular perichondritis external otitis and local infection following upper jaw cancer. Clinical response was excellent in 4 cases and good in 1case showing the effectiveness rate of100%.
As for the side effect, nausea was observed in1case.No abnormal change of laboratory findings was noticed.
Thus, CFS is considered to be the useful drug for the treatment of infection caused by P. aeruginosa in otorhinolaryngological field.
