Bacteriological Evaluation of Midecamycin Acetate and Its Metabolites

Abstract

Midecamycin acetate is a diacetyl derivative of midecamycin1, 2), a macrolide antibiotic with a 16-membered ring, prepared by introducing acyl groups to 9 and 3position of its parent compound, as shown in Fig.1. 3) Its metabolic pathway and chemical structures of its metabolites have already been elucidated from a study on its metabolism4, 5)(Fig.1).
In the present study midecamycin acetate and its metabolites were evaluated bacteriologically both in vitro and in vivo with following results.