Abstract
This paper is concerned with fundamental and clinical studies of ceftizoxime, a newly developed cephalosporin derivative, in the field of obstetrics and gynecology.
1.Concentrations of ceftizoxime after administration 1g of ceftizoxime by1hour drip infusion were determined in genital organs in 17 patients and the exudate of pelvic dead space in 6 patients.Simulated maximal concentrations with the ratios to the simulated peak serum levels were as follows: 27.9, μg/g for fundal myometrium with the ratio of 48%, 36.0μg/gfor portio vaginalis with 62%, 17.1tig/g for ovary with 29%, 15.0 iugig for oviduct with 26% and 16.2, μg/ml for the exudate of pelvic dead space with 30%.
2.Minimal inhibitory concentrations of ceftizoxime were determined against clinically isolated organisms from female genital infectious diseases. Ceftizoxime was found to have a potent in vitro activity against Gram negative bacilli;for example, 0.1, μg/mg or low against E.colt and K.pneumoniae.Against P. aeruginosa, P.cepacia and B.fragilis, ceftizoxime had an activity which expected to be effective in the clinical use.
3.We gave ceftizoxime to 6 patients comprising 4 patients with puerperal fever, 1with septic abortion and 1with tubo-ovarian abscess in daily doses of 2to 3 g by b.i.d or t.i.d intravenous drip infusion for 4 12 days.The results of the treatment were ‘excellent’ in 3 patients, ‘good’ in 2, and ‘unevaluatable’ in 1.
4.Adverse reactions occurred in 2 patients who showed eruption during the medication with ceftizoxime. These patients had allergic histories due to penicillin derivatives.
From the above results it is concluded that ceftizoxime is an useful drug for infections in obstetrical and gynecological field.
